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VPS10P-domain receptors - regulators of neuronal viability and function

Official URL:https://doi.org/10.1038/nrn2516
PubMed:View item in PubMed
Creators Name:Willnow, T.E. and Petersen, C.M. and Nykjaer, A.
Journal Title:Nature Reviews Neuroscience
Journal Abbreviation:Nat Rev Neurosci
Page Range:899-909
Date:December 2008
Keywords:Cell Survival, Biological Models, Nerve Tissue Proteins, Neurons, Protein Transport, Cell Surface Receptors, Signal Transduction, Animals
Abstract:VPS10P-domain receptors, such as SORLA and sortilin, constitute a recently identified class of type-1 receptors that are expressed in neurons. Family members are multifunctional proteins that target a range of ligands, including trophic factors and neuropeptides but also other transmembrane proteins. New findings have revealed unexpected roles for VPS10P-domain receptors as regulators of neuronal viability and function through the regulation of both protein transport and signal transduction. Loss of these activities might contribute to the pathophysiology of devastating disorders of the nervous system, including Alzheimer's disease, affective disorders and post-traumatic neuronal cell death.
Publisher:Nature Publishing Group (U.K.)
Item Type:Review

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