Helmholtz Gemeinschaft


InterPro: the integrative protein signature database

[img] PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader

Item Type:Article
Title:InterPro: the integrative protein signature database
Creators Name:Hunter, S. and Apweiler, R. and Attwood, T.K. and Bairoch, A. and Bateman, A. and Binns, D. and Bork, P. and Das, U. and Daugherty, L. and Duquenne, L. and Finn, R.D. and Gough, J. and Haft, D. and Hulo, N. and Kahn, D. and Kelly, E. and Laugraud, A. and Letunic, I. and Lonsdale, D. and Lopez, R. and Madera, M. and Maslen, J. and McAnulla, C. and McDowall, J. and Mistry, J. and Mitchell, A. and Mulder, N. and Natale, D. and Orengo, C. and Quinn, A.F. and Selengut, J.D. and Sigrist, C.J. and Thimma, M. and Thomas, P.D. and Valentin, F. and Wilson, D. and Wu, C.H. and Yeats, C.
Abstract:The InterPro database (http://www.ebi.ac.uk/interpro/) integrates together predictive models or 'signatures' representing protein domains, families and functional sites from multiple, diverse source databases: Gene3D, PANTHER, Pfam, PIRSF, PRINTS, ProDom, PROSITE, SMART, SUPERFAMILY and TIGRFAMs. Integration is performed manually and approximately half of the total approximately 58 000 signatures available in the source databases belong to an InterPro entry. Recently, we have started to also display the remaining un-integrated signatures via our web interface. Other developments include the provision of non-signature data, such as structural data, in new XML files on our FTP site, as well as the inclusion of matchless UniProtKB proteins in the existing match XML files. The web interface has been extended and now links out to the ADAN predicted protein-protein interaction database and the SPICE and Dasty viewers. The latest public release (v18.0) covers 79.8% of UniProtKB (v14.1) and consists of 16 549 entries. InterPro data may be accessed either via the web address above, via web services, by downloading files by anonymous FTP or by using the InterProScan search software (http://www.ebi.ac.uk/Tools/InterProScan/).
Keywords:Protein Databases, Proteins, Protein Sequence Analysis, Systems Integration
Source:Nucleic Acids Research
Publisher:Oxford University Press
Number:Database Issue
Page Range:D211-D215
Date:January 2009
Official Publication:https://doi.org/10.1093/nar/gkn785
PubMed:View item in PubMed

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library