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STRING 8--a global view on proteins and their functional interactions in 630 organisms

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Item Type:Article
Title:STRING 8--a global view on proteins and their functional interactions in 630 organisms
Creators Name:Jensen, L.J. and Kuhn, M. and Stark, M. and Chaffron, S. and Creevey, C. and Muller, J. and Doerks, T. and Julien, P. and Roth, A. and Simonovic, M. and Bork, P. and von Mering, C.
Abstract:Functional partnerships between proteins are at the core of complex cellular phenotypes, and the networks formed by interacting proteins provide researchers with crucial scaffolds for modeling, data reduction and annotation. STRING is a database and web resource dedicated to protein-protein interactions, including both physical and functional interactions. It weights and integrates information from numerous sources, including experimental repositories, computational prediction methods and public text collections, thus acting as a meta-database that maps all interaction evidence onto a common set of genomes and proteins. The most important new developments in STRING 8 over previous releases include a URL-based programming interface, which can be used to query STRING from other resources, improved interaction prediction via genomic neighborhood in prokaryotes, and the inclusion of protein structures. Version 8.0 of STRING covers about 2.5 million proteins from 630 organisms, providing the most comprehensive view on protein-protein interactions currently available. STRING can be reached at http://string-db.org/.
Keywords:Protein Databases, Genomics, Multiprotein Complexes, Protein Interaction Mapping, Proteins, User-Computer Interface
Source:Nucleic Acids Research
Publisher:Oxford University Press
Number:Database Issue
Page Range:D412-D416
Date:January 2009
Official Publication:https://doi.org/10.1093/nar/gkn760
PubMed:View item in PubMed

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