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Atrial natriuretic peptide induces postprandial lipid oxidation in humans

Item Type:Article
Title:Atrial natriuretic peptide induces postprandial lipid oxidation in humans
Creators Name:Birkenfeld, A.L. and Budziarek, P. and Boschmann, M. and Moro, C. and Adams, F. and Franke, G. and Berlan, M. and Marques, M.A. and Sweep, F.C. and Luft, F.C. and Lafontan, M. and Jordan, J.
Abstract:OBJECTIVE-Atrial natriuretic peptide (ANP) regulates arterial blood pressure. In addition, ANP has recently been shown to promote human adipose tissue lipolysis through cGMP-mediated hormone-sensitive lipase activation. We hypothesized that ANP increases postprandial free fatty acid (FFA) availability and energy expenditure while decreasing arterial blood pressure. RESEARCH DESIGN AND METHODS-We infused human ANP (25 ng . kg(-1) . min(-1)) in 12 men (age 32 +/- 0.8 years, BMI 23.3 +/- 0.4 kg/m(2)) before, during, and 2 h after ingestion of a standardized high-fat test meal in a randomized, double-blind, cross-over fashion. Cardiovascular changes were monitored by continuous electrocardiogram and beat-by-beat blood pressure recordings. Metabolism was monitored through venous blood sampling, intramuscular and subcutaneous abdominal adipose tissue microdialysis, and indirect calorimetry. RESULTS-ANP infusion decreased mean arterial blood pressure by 4 mmHg during the postprandial phase (P < 0.01 vs. placebo). At the same time, ANP induced lipolysis systemically (P < 0.05 vs. placebo) and locally in subcutaneous abdominal adipose tissue (P < 0.0001 vs. placebo), leading to a 50% increase in venous glycerol (P < 0.01) and FFA (P < 0.05) concentrations compared with placebo. The increase in FFA availability with ANP was paralleled by a 15% increase in lipid oxidation rates (P < 0.05 vs. placebo), driving a substantial increase in postprandial energy expenditure (P < 0.05 vs. placebo). CONCLUSIONS-Our data identify the ANP system as a novel pathway regulating postprandial lipid oxidation, energy expenditure, and concomitantly arterial blood pressure. The findings could have therapeutic implications.
Keywords:Adipose Tissue, Atrial Natriuretic Factor, Blood Flow Velocity, Blood Pressure, Energy Metabolism, Intravenous Infusions, Lipids, Lipolysis, Microdialysis, Oxidation-Reduction, Postprandial Period, Reference Values
Source:Diabetes
ISSN:0012-1797
Publisher:American Diabetes Association (U.S.A.)
Volume:57
Number:12
Page Range:3199-3204
Date:December 2008
Official Publication:https://doi.org/10.2337/db08-0649
PubMed:View item in PubMed

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