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The bradykinin B2 receptor in the early immune response against Listeria infection

Item Type:Article
Title:The bradykinin B2 receptor in the early immune response against Listeria infection
Creators Name:Kaman, W.E. and Wolterink, A.F. and Bader, M. and Boele, L.C. and van der Kleij, D.
Abstract:The endogenous danger signal bradykinin was recently found implicated in the development of immunity against parasites via dendritic cells. We here report an essential role of the B(2) (B(2)R) bradykinin receptor in the early immune response against Listeria infection. Mice deficient in B(2)R (B(2)R(-/-) mice) were shown to suffer from increased hepatic bacterial burden and concomitant dramatic weight loss during infection with Listeria monocytogenes. Levels of cytokines known to play a pivotal role in the early phase immune response against L. monocytogenes, IL-12p70 and IFN-gamma, were reduced in B(2)R(-/-) mice. To extend these findings to the human system, we show that bradykinin potentiates the production of IL-12p70 in human monocyte-derived dendritic cells. Thus, we show that bradykinin and the B(2)R play a role in early innate immune functions during bacterial infection.
Keywords:Bradykinin, Listeria Monocytogenes, Cytokines, Knock Out Mice, Animals, Mice
Source:Medical Microbiology and Immunology
ISSN:0300-8584
Publisher:Springer
Volume:198
Number:1
Page Range:39-46
Date:February 2009
Official Publication:https://doi.org/10.1007/s00430-008-0103-4
PubMed:View item in PubMed

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