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| Item Type: | Article |
|---|---|
| Title: | No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individuals |
| Creators Name: | Patkar, A.A. and Berrettini, W.H. and Hoehe, M. and Hill, K.P. and Gottheil, E. and Thornton, C.C. and Weinstein, S.P. |
| Abstract: | Genetic research of cocaine abuse has been relatively limited among the African-American population. Since the serotonin transporter (5HTT) may be involved in modulating effects of cocaine, we investigated whether allelic variants of the 5HTT gene may confer susceptibility to cocaine dependence among African-American individuals. One hundred and fifty-six cocaine-dependent subjects and 82 controls were studied. Polymerase chain reaction-based genotyping of a variable-number-tandem-repeat (VNTR) marker yielded three alleles designated 12, 10 and 9. Genotype and allele frequencies were compared using chi-square analyses. We found no differences between subjects and controls with respect to genotype distribution (cocaine: 12/12 = 50%, 10/12 = 35.3%, 10/10 = 13.5%, 9/12 = 1.3%; controls: 12/12 = 42.7%, 10/12 = 39.0%, 10/10 = 17.1%, 9/12 = 1.2%). Similarly, allele frequencies of the VNTR marker did not differ between the two groups (cocaine: 12 = 68.3%, 10 = 31.1%, 9 = 0.6%; controls: 12 = 62.8%, 10 = 36.6%, 9 = 0.6%). Our findings do not seem to support a relationship between VNTR polymorphisms and cocaine dependence among African-American patients. Further studies involving larger samples are required to confirm our results. |
| Keywords: | Cocaine Dependence, Serotonin Transporter, Gene, Polymorphisms, African-American, Variable Number Tandem Repeat |
| Source: | Psychiatric Genetics |
| ISSN: | 0955-8829 |
| Publisher: | Lippincott Williams & Wilkins |
| Volume: | 12 |
| Number: | 3 |
| Page Range: | 161-164 |
| Date: | September 2002 |
| Official Publication: | http://www.psychgenetics.com/pt/re/psychgen/abstract.00041444-200209000-00007.htm |
| PubMed: | View item in PubMed |
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