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Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients

Item Type:Article
Title:Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients
Creators Name:Jordan, J. and Greenway, F.L. and Leiter, L.A. and Li, Z. and Jacobson, P. and Murphy, K. and Hill, J. and Kler, L. and Aftring, R.P.
Abstract:Cholecystokinin (CCK) decreases meal size through activation of CCK-A receptors on vagal afferents. We tested the hypothesis that the selective CCK-A agonist GI181771X induces weight loss in obese patients. Patients with body mass index > or = 30 or > or = 27 kg/m2 with concomitant risk factors were randomized to 24-week, double-blind treatment with different GI181771X doses or matching placebo together with a hypocaloric diet. The primary efficacy end point was the absolute change in body weight. To monitor pancreatic and gallbladder effects, patients underwent abdominal ultrasound and magnetic resonance imaging before and after treatment. We randomized 701 patients to double-blind treatment. GI181771X did not reduce body weight and had no effect on waist circumference or other cardiometabolic risk markers. Gastrointestinal side effects were more common with GI181771X than with placebo treatment, whereas hepatobiliary or pancreatic abnormalities did not occur. CCK-A by itself does not have a central role in long-term energy balance.
Keywords:Anti-Obesity Agents, Benzodiazepines, Caloric Restriction, Combined Modality Therapy, Double-Blind Method, Gallbladder, Liver, Magnetic Resonance Imaging, Obesity, Pancreas, Cholecystokinin A Receptor, Time Factors, Treatment Outcome, Ultrasonography, Weight Loss
Source:Clinical Pharmacology and Therapeutics
ISSN:0009-9236
Publisher:Nature Publishing Group (U.S.A.)
Volume:83
Number:2
Page Range:281-287
Date:February 2008
Official Publication:https://doi.org/10.1038/sj.clpt.6100272
PubMed:View item in PubMed

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