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Linear motif atlas for phosphorylation-dependent signaling

Item Type:Article
Title:Linear motif atlas for phosphorylation-dependent signaling
Creators Name:Miller, M.L. and Jensen, L.J. and Diella, F. and Jorgensen, C. and Tinti, M. and Li, L. and Hsiung, M. and Parker, S.A. and Bordeaux, J. and Sicheritz-Ponten, T. and Olhovsky, M. and Pasculescu, A. and Alexander, J. and Knapp, S. and Blom, N. and Bork, P. and Li, S. and Cesareni, G. and Pawson, T. and Turk, B.E. and Yaffe, M.B. and Brunak, S. and Linding, R.
Abstract:Systematic and quantitative analysis of protein phosphorylation is revealing dynamic regulatory networks underlying cellular responses to environmental cues. However, matching these sites to the kinases that phosphorylate them and the phosphorylation-dependent binding domains that may subsequently bind to them remains a challenge. NetPhorest is an atlas of consensus sequence motifs that covers 179 kinases and 104 phosphorylation-dependent binding domains [Src homology 2 (SH2), phosphotyrosine binding (PTB), BRCA1 C-terminal (BRCT), WW, and 14-3-3]. The atlas reveals new aspects of signaling systems, including the observation that tyrosine kinases mutated in cancer have lower specificity than their non-oncogenic relatives. The resource is maintained by an automated pipeline, which uses phylogenetic trees to structure the currently available in vivo and in vitro data to derive probabilistic sequence models of linear motifs. The atlas is available as a community resource (http://netphorest.info).
Keywords:14-3-3 Proteins, Amino Acid Motifs, BRCA1 Protein, Consensus Sequence, Protein Databases, Phosphorylation, Phosphotransferases, Phosphotyrosine, Protein Binding, Signal Transduction, src Homology Domains, Animals
Source:Science Signaling
ISSN:1937-9145
Publisher:American Association for the Advancement of Science (U.S.A.)
Volume:1
Number:35
Page Range:ra2
Date:2 September 2008
Official Publication:https://doi.org/10.1126/scisignal.1159433
PubMed:View item in PubMed

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