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Gender-specific differences in left ventricular remodelling and fibrosis in hypertrophic cardiomyopathy: Insights from cardiovascular magnetic resonance

Item Type:Article
Title:Gender-specific differences in left ventricular remodelling and fibrosis in hypertrophic cardiomyopathy: Insights from cardiovascular magnetic resonance
Creators Name:Schulz-Menger, J. and Abdel-Aty, H. and Rudolf, A. and Elgeti, T. and Messroghli, D. and Utz, W. and Boye, P. and Bohl, S. and Busjahn, A. and Hamm, B. and Dietz, R.
Abstract:BACKGROUND: Gender is an independent risk factor for heart failure mortality in hypertrophic cardiomyopathy (HCM). AIMS: To explore the interaction between gender, myocardial fibrosis and remodelling in HCM. METHODS: We studied 64 HCM patients (28 females, aged 51+/-16 years) categorized as non-obstructive (HNCM, n=31) or obstructive (HOCM, n=33) and 60 healthy subjects (31 females, aged 43+/-14 years). Cine imaging was performed to assess left ventricular volumes and mass. LV remodelling index (LVRI) was calculated. Extension of late gadolinium enhancement (LGE) was quantified. RESULTS: Females in the control group and in the HNCM group had a lower LVRI than males (control: 0.7+/-0.1 vs. 0.9+/-0.2 g/ml, p<0.002; HNCM: 1.1+/-0.2 vs. 1.5+/-0.5 g/ml, p<0.001). In contrast, HOCM females had a similar LVRI compared to males (1.8+/-0.5 vs. 1.7+/-0.4 g/ml, p=ns). Thus the increase in LVRI was more pronounced in females compared to males. LGE was noted in 70% of the patients. No relation was found between the presence or the quantity of myocardial fibrosis and gender in any of the patient subgroups. CONCLUSION: Our data suggest a disproportionate degree of remodelling in different forms of HCM depending on gender. Gender does not appear to influence the quantity of fibrosis as defined by LGE.
Keywords:Hypertrophic Cardiomyopathy, Gender, Cardiovascular Magnetic Resonance, Late Gadolinium Enhancement
Source:European Journal of Heart Failure
ISSN:1388-9842
Publisher:Elsevier (The Netherlands)
Volume:10
Number:9
Page Range:850-854
Date:September 2008
Official Publication:https://doi.org/10.1016/j.ejheart.2008.06.021
PubMed:View item in PubMed

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