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Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3{alpha}

Official URL:https://doi.org/10.1182/blood-2008-01-134783
PubMed:View item in PubMed
Creators Name:Lamprecht, B. and Kreher, S. and Anagnostopoulos, I. and Joehrens, K. and Monteleone, G. and Jundt, F. and Stein, H. and Janz, M. and Doerken, B. and Mathas, S.
Journal Title:Blood
Journal Abbreviation:Blood
Page Range:3339-3347
Date:15 October 2008
Keywords:CD95 Antigens, CD4-Positive T-Lymphocytes, Tumor Cell Line, Cell Lineage, Cell Proliferation, Chemokine CCL20, Neoplastic Gene Expression Regulation, Hodgkin Disease, Immune System, Interleukin-6, Interleukins, STAT3 Transcription Factor, Regulatory T-Lymphocytes, Th2 Cells
Abstract:The malignant Hodgkin-/Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (HL) are derived from mature B cells, but have lost a considerable part of the B cell-specific gene expression pattern. Consequences of such a lineage infidelity for lymphoma pathogenesis are currently not defined. Here, we report that HRS cells aberrantly express the common cytokine-receptor gamma-chain (gammac) cytokine IL-21, which is usually restricted to a subset of CD4(+) T cells, and the corresponding IL-21 receptor. We demonstrate that IL-21 activates STAT3 in HRS cells, up-regulates STAT3 target genes, and protects HRS cells from CD95 death receptor-induced apoptosis. Furthermore, IL-21 is involved in up-regulation of the CC chemokine macrophage-inflammatory protein-3alpha (MIP-3alpha) in HRS cells. MIP-3alpha in turn attracts CCR6(+)CD4(+)CD25(+)FoxP3(+)CD127(lo) regulatory T cells towards HRS cells, which might favour their immune escape. Together, these data support the concept that aberrant expression of B lineage-inappropriate genes plays an important role for the biology of HL tumor cells.
Publisher:American Society of Hematology (U.S.A.)
Item Type:Article

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