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PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element

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Official URL:https://doi.org/10.1101/gad.1654808
PubMed:View item in PubMed
Creators Name:Ebralidze, A.K. and Guibal, F.C. and Steidl, U. and Zhang, P. and Lee, S. and Bartholdy, B. and Jorda, M.A. and Petkova, V. and Rosenbauer, F. and Huang, G. and Dayaram, T. and Klupp, J. and O'Brien, K.B. and Will, B. and Hoogenkamp, M. and Borden, K.L. and Bonifer, C. and Tenen, D.G.
Journal Title:Genes & Development
Journal Abbreviation:Genes Dev
Page Range:2085-2092
Date:1 August 2008
Keywords:Noncoding Antisense RNA, Upstream and Intronic Regulatory Elements, Coordinated Expression of the Target and Regulator, Translation Stalling, Animals, Mice
Abstract:The transcription factor PU.1 is an important regulator of hematopoiesis; precise expression levels are critical for normal hematopoietic development and suppression of leukemia. We show here that noncoding antisense RNAs are important modulators of proper dosages of PU.1. Antisense and sense RNAs are regulated by shared evolutionarily conserved cis-regulatory elements, and we can show that antisense RNAs inhibit PU.1 expression by modulating mRNA translation. We propose that such antisense RNAs will likely be important in the regulation of many genes and may be the reason for the large number of overlapping complementary transcripts with so far unknown function.
Publisher:Cold Spring Harbor Laboratory Press (U.S.A.)
Item Type:Article

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