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Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension

Official URL:https://doi.org/10.1038/ng.164
PubMed:View item in PubMed
Creators Name:Pravenec, M. and Churchill, P.C. and Churchill, M.C. and Viklicky, O. and Kazdova, L. and Aitman, T.J. and Petretto, E. and Huebner, N. and Wallace, C.A. and Zimdahl, H. and Zidek, V. and Landa, V. and Dunbar, J. and Bidani, A. and Griffin, K. and Qi, N. and Maxova, M. and Kren, V. and Mlejnek, P. and Wang, J. and Kurtz, T.W.
Journal Title:Nature Genetics
Journal Abbreviation:Nat Genet
Volume:40
Number:8
Page Range:952-954
Date:August 2008
Keywords:CD36 Antigens, Hypertension, Kidney, Quantitative Trait Loci, Inbred SHR Rats, Animals, Rats
Abstract:To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension.
ISSN:1061-4036
Publisher:Nature Publishing Group (U.S.A.)
Item Type:Article

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