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Bisoprolol vs. carvedilol in elderly patients with heart failure: rationale and design of the CIBIS-ELD trial

Item Type:Article
Title:Bisoprolol vs. carvedilol in elderly patients with heart failure: rationale and design of the CIBIS-ELD trial
Creators Name:Duengen, H.D. and Apostolovic, S. and Inkrot, S. and Tahirovic, E. and Krackhardt, F. and Pavlovic, M. and Putnikovic, B. and Lainscak, M. and Gelbrich, G. and Edelmann, F. and Wachter, R. and Eschenhagen, T. and Waagstein, F. and Follath, F. and Rauchhaus, M. and Haverkamp, W. and Osterziel, K.J. and Dietz, R.
Abstract:BACKGROUND: Chronic heart failure (CHF) is a widespread disease with severe quality of life impairment and a poor prognosis. Beta-blockers are the mainstay of CHF therapy; yet they are under-prescribed and under-dosed in clinical practice. This is particularly evident in elderly patients, which may be due to a fear of side-effects or intolerance. Beta-blockers have further not been adequately tested in patients with diastolic CHF, which is particularly common in elderly patients. Finally, comparative data on the use of different beta-blockers in patients with CHF is scarce. AIM: To compare the tolerance of bisoprolol and carvedilol in elderly patients with CHF. METHODS: CIBIS-ELD is an investigator-initiated, multi-centre, 1:1 randomised, double-blind, phase III trial comparing bisoprolol and carvedilol in patients >/=65 years with systolic or diastolic CHF. Recruitment started in April 2005 and is anticipated to be completed by April 2008 with at least 800 patients enrolled. PERSPECTIVE: This is the first large scale head to head beta-blockers trial in an elderly population with CHF. Besides determining which of two standard beta-blockers is best tolerated in elderly patients with systolic or diastolic CHF, we expect to gain further insight into the treatment of the particular population of patients with diastolic CHF.
Keywords:Chronic Heart Failure, Bisoprolol, Carvedilol, Tolerance, Head-to-Head
Source:Clinical Research in Cardiology
ISSN:1861-0684
Publisher:Steinkopff (Germany)
Volume:97
Number:9
Page Range:578-586
Date:September 2008
Official Publication:https://doi.org/10.1007/s00392-008-0681-6
PubMed:View item in PubMed

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