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Angiotensin II stimulates angiogenesis in the chorio-allantoic membrane of the chick embryo

Item Type:Letter
Title:Angiotensin II stimulates angiogenesis in the chorio-allantoic membrane of the chick embryo
Creators Name:Le Noble, F.A. and Hekking, J.W. and Van Straaten, H.W. and Slaaf, D.W. and Struyker Boudier, H.A.
Abstract:Angiotensin II was applied daily in doses of 67 or 670 ng to a section of the chick embryo chorio-allantoic membrane from day 7 to day 14 after fertilization of the eggs. During this one-week period, it caused a significant, dose-dependent increase in the vascular density index. The increase obtained with 670 ng daily was comparable to that after daily administration of 1.7 micrograms adenosine, a known stimulator of angiogenesis. The data suggest a possible role for angiotensin II as a mediator of vascular growth.
Keywords:Angiogenesis, Angiotensin II, Hypertension, Chorio-Allantoic Membrane, Blood Vessels, Animals, Chickens
Source:European Journal of Pharmacology - Molecular Pharmacology Section
ISSN:0014-2999
Publisher:Elsevier
Volume:195
Number:2
Page Range:305-306
Date:26 March 1991
Official Publication:https://doi.org/10.1016/0014-2999(91)90552-2
PubMed:View item in PubMed

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