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The microcirculation and hypertension

Item Type:Article
Title:The microcirculation and hypertension
Creators Name:Struijker Boudier, H.A.J. and Le Noble, J.L.M.L. and Messing, M.W.J. and Huijberts, M.S.P. and le Noble, F.A.C. and van Essen, H.
Abstract:AIM: To review published evidence on the effects of arteriolar changes in primary and secondary hypertension. BACKGROUND: Pressure profile analyses have shown that the microcirculation is a major site of vascular resistance. With the recent refinement of intravital microscopy techniques detailed information has become available on mechanisms of the microvascular resistance increase in hypertension. Three mechanisms play an important role: (1) a decrease in arteriolar diameter; (2) arteriolar vessel wall hypertrophy; and (3) small arteriolar and capillary rarefaction. METHOD: The evidence was synthesized into a hypothesis on the role of the microcirculation in primary forms of hypertension. HYPOTHESIS: The hypothesis formulated contains two important elements in that (1) diminished outgrowth of the microvascular bed in different tissues is seen as an important early pathogenic mechanism; and (2) the decreases in arteriolar diameter and vessel wall hypertrophy are seen as adaptive mechanisms that maintain a constant wall stress. The three factors together maintain the increase in vascular resistance that is common to all established forms of primary hypertension.
Keywords:Arterioles, Hypertension, Hypertrophy, Microcirculation, Vascular Resistance, Animals
Source:Journal of Hypertension
Publisher:Lippincott Williams & Wilkins
Number:Suppl 7
Page Range:S147-S156
Date:December 1992
Official Publication:http://ovidsp.tx.ovid.com/spa/ovidweb.cgi?&S=NCHPFPIIDODDCGBINCGLNDJJMFAEAA00&Complete+Reference=S.sh.15.16.40%7c16%7c1
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