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Guidance of vascular and neural network formation

Item Type:Review
Title:Guidance of vascular and neural network formation
Creators Name:Eichmann, A. and le Noble, F. and Autiero, M. and Carmeliet, P.
Abstract:Blood vessels and nerves are structurally similar complex branched systems. Their guidance must be exquisitely regulated to ensure proper wiring of both networks. Recent results showed that specialized endothelial cells, resembling axonal growth cones, form the tips of growing capillaries. These endothelial tip cells guide outgrowing capillaries in response to gradients of extracellular matrix-bound vascular endothelial growth factor. Several axon guidance molecules, including Semaphorins, Netrins, Ephrins and Slits, have also been implicated in vessel pathfinding and network formation. In particular, Semaphorin3E and its receptor plexinD1 in addition to the Netrin receptor UNC5B have recently been shown to direct endothelial tip cell navigation.
Keywords:Vascular Endothelium, Growth Cones, Physiologic Neovascularization, Nerve Net, Animals
Source:Current Opinion in Neurobiology
Page Range:108-115
Date:February 2005
Official Publication:https://doi.org/10.1016/j.conb.2005.01.008
PubMed:View item in PubMed

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