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The effects of chromosome 17 on features of the metabolic syndrome in the Lyon Hypertensive (LH) rat

Item Type:Article
Title:The effects of chromosome 17 on features of the metabolic syndrome in the Lyon Hypertensive (LH) rat
Creators Name:Gilibert, S. and Kwitek, A.E. and Huebner, N. and Tschannen, M. and Jacob, H.J. and Sassard, J. and Bataillard, A.P.
Abstract:The metabolic syndrome (involving obesity, hypertension, dyslipidemia, insulin resistance, and a proinflammatory/prethrombotic state), is a major risk factor for cardiovascular disease. Its incidence continues to rise, in part because of the epidemic increase in obesity. The Lyon Hypertensive (LH) rat is a model for hypertension and several other features for the metabolic syndrome, having high body weight, plasma cholesterol and triglycerides, increased insulin/glucose ratio, and salt-sensitive hypertension. Previous genetic studies in LH/Mav and a normotensive control (LN/Mav) identified Quantitative Trait Loci (QTLs) on rat chromosome (RNO) 17 for multiple features of the metabolic syndrome. To further evaluate the role of RNO17 in the LH, we generated a consomic strain (LH-17(BN)) by substituting LH RNO17 with that of the sequenced Brown Norway (BN/NHsdMcwi) rat. Male LH and BN, and LH-17(BN) rats were characterized for blood pressure, metabolic and morphological parameters. Similar to the protective effect of LN alleles, the LH-17(BN) also shows decreased body weight, triglycerides, and blood pressure; however there was no significant difference in cholesterol or insulin/glucose ratios. Therefore, the substitution of the LH chromosome 17 is sufficient to recapitulate some, but not all, of the traits previously mapped to this chromosome. This could be due to the lack of a susceptible LH genome background or due to the introgression of chromosome 17 from another strain. Regardless, this study provides a single-chromosome genetic model for further dissection of blood pressure, morphological, and metabolic traits on this chromosome. Key words: rat, consomic, hypertension, metabolic syndrome.
Keywords:Consomic, Hypertension, Animals, Rats
Source:Physiological Genomics
ISSN:1094-8341
Publisher:American Physiological Society (U.S.A.)
Volume:33
Number:2
Page Range:212-217
Date:22 April 2008
Official Publication:https://doi.org/10.1152/physiolgenomics.00262.2007
PubMed:View item in PubMed

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