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G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

Official URL:https://doi.org/10.1038/ng.84
PubMed:View item in PubMed
Creators Name:Pasternack, S.M. and von Kuegelgen, I. and Aboud, K.A. and Lee, Y.A. and Rueschendorf, F. and Voss, K. and Hillmer, A.M. and Molderings, G.J. and Franz, T. and Ramirez, A. and Nuernberg, P. and Noethen, M.M. and Betz, R.C.
Journal Title:Nature Genetics
Journal Abbreviation:Nat Genet
Volume:40
Number:3
Page Range:329-334
Date:March 2008
Keywords:Base Sequence, Biological Models, Cercopithecus aethiops, Chromosome Mapping, Consanguinity, COS Cells, DNA Mutational Analysis, Family, G-Protein-Coupled Receptors, Hair, Hypotrichosis, Lysophospholipids, Pair Human 13 Chromosomes, Pedigree, Phylogeny, Purinergic P2 Receptors, Transfection, Animals
Abstract:Hypotrichosis simplex is a group of nonsyndromic human alopecias. We mapped an autosomal recessive form of this disorder to chromosome 13q14.11-13q21.33, and identified homozygous truncating mutations in P2RY5, which encodes an orphan G protein-coupled receptor. Furthermore, we identified oleoyl-L-alpha-lysophosphatidic acid (LPA), a bioactive lipid, as a ligand for P2Y5 in reporter gene and radioligand binding experiments. Homology and studies of signaling transduction pathways suggest that P2Y5 is a member of a subgroup of LPA receptors, which also includes LPA4 and LPA5. Our study is the first to implicate a G protein-coupled receptor as essential for and specific to the maintenance of human hair growth. This finding may provide opportunities for new therapeutic approaches to the treatment of hair loss in humans.
ISSN:1061-4036
Publisher:Nature Publishing Group (U.S.A.)
Item Type:Article

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