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Cortactin: an Achilles' heel of the actin cytoskeleton targeted by pathogens

Item Type:Review
Title:Cortactin: an Achilles' heel of the actin cytoskeleton targeted by pathogens
Creators Name:Selbach, M. and Backert, S.
Abstract:Cortactin is an actin-binding protein and a central regulator of the actin cytoskeleton. Importantly, cortactin is also a common target exploited by microbes during infection. Its involvement in disease development is exemplified by a variety of pathogenic processes, such as pedestal formation [enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC)], invasion (Shigella, Neisseria, Rickettsia, Chlamydia, Staphylococcus and Cryptosporidium), actin-based motility (Listeria, Shigella and vaccinia virus) and cell scattering (Helicobacter). Recent progress turns our attention to how cortactin function can be regulated by serine and tyrosine phosphorylation. This has an important impact on how pathogens abuse cortactin to modulate the architecture of the host actin cytoskeleton.
Keywords:Actins, Bacteria, Bacterial Infections, Cortactin, Cytoskeleton, Microfilament Proteins, Biological Models
Source:Trends in Microbiology
Page Range:181-189
Date:April 2005
Official Publication:https://doi.org/10.1016/j.tim.2005.02.007
PubMed:View item in PubMed

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