Helmholtz Gemeinschaft


Tyrosine-phosphorylated bacterial effector proteins: the enemies within

Item Type:Review
Title:Tyrosine-phosphorylated bacterial effector proteins: the enemies within
Creators Name:Backert, S. and Selbach, M.
Abstract:The tyrosine phosphorylation of proteins has a central role during signal transduction in eukaryotes. Recent progress shows that tyrosine phosphorylation is also a common feature of several effector proteins translocated by bacterial type III and type IV secretion systems. The involvement of these secretion systems in disease development is exemplified by a variety of pathogenic processes: pedestal formation (Tir of EPEC and Citrobacter), cell scattering (CagA of Helicobacter), invasion (Tarp of Chlamydia) and possibly proinflammatory responses and cell proliferation (BepD-F of Bartonella). The discovery that different bacterial pathogens use this common strategy to subvert host-cell function suggests that more examples will soon emerge.
Keywords:Bacterial Antigens, Bacterial Physiology, Bacterial Proteins, Escherichia coli Proteins, Phosphorylation, Cell Surface Receptors, Tyrosine
Source:Trends in Microbiology
Publisher:Elsevier Science London
Page Range:476-484
Date:October 2005
Official Publication:https://doi.org/10.1016/j.tim.2005.08.002
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library