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E-I balance and human diseases - from molecules to networking

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Item Type:Article
Title:E-I balance and human diseases - from molecules to networking
Creators Name:Eichler, S.A. and Meier, J.C.
Abstract:Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development. This review contains recent information about the molecular mechanisms orchestrating the establishment and maintenance of this excitation-inhibition (E-I) balance, and it reviews examples of deregulation of inhibitory and excitatory systems at a molecular, network and disease level of investigation.
Keywords:Development, Excitation-inhibition balance, Homeostasis, Hyperexcitability, Autism, Nervous system disorders, Excitation, Inhibition, E-I balance, Mental retardation, Schizophrenia, Alzheimer's disease, Rett Syndrome
Source:Frontiers in Molecular Neuroscience
ISSN:1662-5099
Publisher:Frontiers Research Foundation (U.S.A.)
Volume:1
Number:2
Date:28 March 2008
Official Publication:https://doi.org/10.3389/neuro.02.002.2008
PubMed:View item in PubMed

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