Helmholtz Gemeinschaft


Inhibition of alpha-subunit glycine receptors by quinoxalines

Item Type:Article
Title:Inhibition of alpha-subunit glycine receptors by quinoxalines
Creators Name:Meier, J. and Schmieden, V.
Abstract:Quinoxalines are widely used compounds in electrophysiological studies to separate excitatory and inhibitory neurotransmission mediated by the strychnine-insensitive and strychnine-sensitive glycine receptor (NMDA, GlyR), respectively. We report here, that the quinoxaline NBQX is a potent antagonist of homo-oligomeric alpha1- and alpha2-subunit glycine receptors expressed in Xenopus laevis oocytes. NBQX elicited half-maximal inhibition of glycine evoked currents at a concentration of about 5 microM. DNQX and CNQX were found to be 5-fold and 20-fold less efficient than NBQX. At oocytes expressing alpha1beta2 subunit GABAA receptors the quinoxalines tested showed no significant inhibition of GABA responses up to a concentration of 100 microM. Our data indicates that these quinoxalines applied at concentrations sufficient to block NMDA receptor also attenuate GlyR responses.
Keywords:6-Cyano-7-nitroquinoxaline-2,3-dione, Algorithms, Drug Dose-Response Relationship, Electrophysiology, Oocytes, Quinoxalines, GABA-A Receptors, Glycine Receptors, Xenopus laevis, Animals, Frogs
Publisher:Lippincott Williams & Wilkins
Page Range:1507-1510
Date:6 August 2003
Official Publication:https://doi.org/10.1097/01.wnr.0000085903.20980.2f
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library