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Kv7 channels: interaction with dopaminergic and serotonergic neurotransmission in the CNS

Item Type:Article
Title:Kv7 channels: interaction with dopaminergic and serotonergic neurotransmission in the CNS
Creators Name:Hansen, H.H. and Waroux, O. and Seutin, V. and Jentsch, T.J. and Aznar, S. and Mikkelsen, J.D.
Abstract:Neuronal Kv7 channels (also termed KCNQ channels) are the molecular correlate of the M-current. The Kv7 channels activate at rather negative membrane potentials (< 60 mV), thereby 'fine-tuning' the resting membrane potential. The Kv7 channels are widely expressed in the brain with the Kv7.2, Kv7.3 and Kv7.5 channels being the most abundant. The Kv7.4 subunit has the most restricted brain regional expression being present in discrete nuclei of brain stem only. Kv7 channels are expressed at different subcellular locations, being on both somatodendritic, axonal and terminal sites. This complex subcellular distribution of Kv7 channels enables them to participate in both pre- and postsynaptic modulation of basal and stimulated excitatory neurotransmission. Activation of neuronal Kv7 channels limits repetitive firing thereby potentially limiting the generation of long burst, with subsequent inhibition of monoaminergic neurotransmitter release. In this review, we focus on the influence of Kv7 channels on dopaminergic and serotonergic neurotransmission. These data suggest a novel action of Kv7 channel openers which could translate into therapeutic value in the treatment of disease states characterized by overactivity of dopaminergic (e.g. schizophrenia and drug abuse) and serotonergic neurotransmission (e.g. anxiety).
Keywords:Dopamine, Ion channel, Serotonin, Kv7 channels, M-current
Source:Journal of Physiology
Page Range:1823-1832
Date:1 April 2008
Official Publication:https://doi.org/10.1113/jphysiol.2007.149450
PubMed:View item in PubMed

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