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Roles of the kallikrein/kinin system in the adaptive immune system

Item Type:Article
Title:Roles of the kallikrein/kinin system in the adaptive immune system
Creators Name:Schulze-Topphoff, U. and Prat, A. and Bader, M. and Zipp, F. and Aktas, O.
Abstract:This review deals with the effects of kinins, a family of octa- to decapeptides structurally related to bradykinin (BK), in adaptive immune responses. Herein, we discuss the experimental evidence that kinins may exert influence on multiple players of the immune system (i.e. macrophages, dendritic cells, T and B lymphocytes), and modulate the activation, proliferation, migration and effector functions of these cells. We also give an overview of the possible impact of kinins in human autoimmune diseases and corresponding animal models, with special emphasis on autoimmune neuroinflammation and arthritis. These studies indicate a possible immunomodulatory capacity of kinins beyond our current knowledge of kinin actions regarding the vascular system, and thus the way towards future therapeutic approaches.
Keywords:Bradykinin, Immune system, Autoimmunity, Multiple sclerosis, Experimental autoimmune encephalomyelitis, Animals, Mice
Source:International Immunopharmacology
ISSN:1567-5769
Publisher:Elsevier (The Netherlands)
Volume:8
Number:2
Page Range:155-160
Date:February 2008
Additional Information:The original publication is available at www.sciencedirect.com
Official Publication:https://doi.org/10.1016/j.intimp.2007.08.001
PubMed:View item in PubMed

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