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Neuronal damage in brain inflammation

Item Type:Article
Title:Neuronal damage in brain inflammation
Creators Name:Aktas, O. and Ullrich, O. and Infante-Duarte, C. and Nitsch, R. and Zipp, F.
Abstract:In contrast to traditional textbook paradigms, recent studies indicate neuronal damage in classic neuroinflammatory diseases of the brain, such as multiple sclerosis or meningitis. In these cases, immune cells invade the central nervous system compartments, accompanied by a massive breakdown of the blood-brain barrier and typical changes of the cerebrospinal fluid. On the other hand, inflammation within the central nervous system is a common phenomenon even in classic noninflammatory brain diseases that are characterized by degeneration or trauma of neuronal structures, such as Alzheimer disease, Parkinson disease, or stroke. In these cases, inflammation is a frequent occurrence but displays different, more subtle, patterns compared with, for example, multiple sclerosis. Concepts for directly protecting neurons and axons in neuroinflammatory diseases may improve the outcome of the patients. In parallel, epidemiological and animal experimental evidences, as well as first clinical trials indicate the benefit of immunomodulatory therapies for classic noninflammatory brain diseases. We review the evidence for inflammatory neuronal damage and its clinical impact in the context of these diseases.
Keywords:Biological Models, Encephalitis, Neurons, Animals
Source:Archives of Neurology
ISSN:0003-9942
Publisher:American Medical Association (U.S.A.)
Volume:64
Number:2
Page Range:185-189
Date:February 2007
Official Publication:https://doi.org/10.1001/archneur.64.2.185
PubMed:View item in PubMed

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