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Early maturation of GABAergic synapses in mouse retinal ganglion cells

Item Type:Article
Title:Early maturation of GABAergic synapses in mouse retinal ganglion cells
Creators Name:Unsoeld, T. and Stradomska, A.M. and Wang, R. and Rathjen, F.G. and Juettner, R.
Abstract:This study was aimed to characterize the earliest phases of synapse development in mouse retinal ganglion cells (RGCs) by recording spontaneous postsynaptic currents (PSCs). First PSCs were detected at embryonic day 17 and completely suppressed by bicuculline, demonstrating their GABAergic nature. Starting from postnatal day 3 a small fraction of RGCs had rapidly decaying, most likely glutamatergic currents. The present results suggest that functional GABAergic synapses with RGCs appear before birth and that GABAergic synaptic transmission precedes that of glutamate in the retina. In this early period GABA acts in a depolarizing manner and takes over an excitatory function.
Keywords:GABA, Development, Retina, Synaptic transmission, Synaptogenesis, Animals, Mice
Source:International Journal of Developmental Neuroscience
ISSN:0736-5748
Publisher:Elsevier (The Netherlands)
Volume:26
Number:2
Page Range:233-238
Date:April 2008
Official Publication:https://doi.org/10.1016/j.ijdevneu.2007.12.001
PubMed:View item in PubMed

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