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Leukoencephalopathy upon disruption of the chloride channel ClC-2

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Item Type:Article
Title:Leukoencephalopathy upon disruption of the chloride channel ClC-2
Creators Name:Blanz, J. and Schweizer, M. and Auberson, M. and Maier, H. and Muenscher, A. and Huebner, C.A. and Jentsch, T.J.
Abstract:ClC-2 is a broadly expressed plasma membrane chloride channel that is modulated by voltage, cell swelling, and pH. A human mutation leading to a heterozygous loss of ClC-2 has previously been reported to be associated with epilepsy, whereas the disruption of Clcn2 in mice led to testicular and retinal degeneration. We now show that the white matter of the brain and spinal cord of ClC-2 knock-out mice developed widespread vacuolation that progressed with age. Fluid-filled spaces appeared between myelin sheaths of the central but not the peripheral nervous system. Neuronal morphology, in contrast, seemed normal. Except for the previously reported blindness, neurological deficits were mild and included a decreased conduction velocity in neurons of the central auditory pathway. The heterozygous loss of ClC-2 had no detectable functional or morphological consequences. Neither heterozygous nor homozygous ClC-2 knock-out mice had lowered seizure thresholds. Sequencing of a large collection of human DNA and electrophysiological analysis showed that several ClC-2 sequence abnormalities previously found in patients with epilepsy most likely represent innocuous polymorphisms.
Keywords:Leukodystrophy, Oligodendrocyte, Glia, Knock-out, Anion transport, Animals, Mice
Source:Journal of Neuroscience
Publisher:Society for Neuroscience
Page Range:6581-9
Date:13 June 2007
Official Publication:https://doi.org/10.1523/JNEUROSCI.0338-07.2007
PubMed:View item in PubMed

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