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The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains

Item Type:Article
Title:The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains
Creators Name:Tenner, K. and Qadri, F. and Bert, B. and Voigt, J.P. and Bader, M.
Abstract:Tryptophan hydroxylase 2 (TPH2) is the rate limiting enzyme of serotonin synthesis in the brain. A recently described functional (C1473G) single nucleotide polymorphism in mouse TPH2 resulting in vitro in a strongly decreased enzymatic activity was suspected to be responsible for the observed differences in 5-HT levels and behaviour between mice strains. We bred two substrains of C57BL/6 mice carrying the two isoforms and could show that both exhibit equal TPH activity, brain 5-HT content and behaviour. These data indicate that the distinct behavioural characteristics of mouse strains are not due to differences in TPH2 activity, but to other variations in the genetic background.
Keywords:TPH, Serotonin, C1473G Polymorphism, Behaviour, Animals, Mice
Source:Neuroscience Letters
ISSN:0304-3940
Publisher:Elsevier (The Netherlands)
Volume:431
Number:1
Page Range:21-25
Date:24 January 2008
Additional Information:The original publication is available at http://www.sciencedirect.com/
Official Publication:https://doi.org/10.1016/j.neulet.2007.11.012
PubMed:View item in PubMed

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