Experiments to increase the selectivity of tumor chemotherapy by means of in vivo activation of transport forms of cancerostatics by exogenous enzymes

Item Type:	Article
Title:	Experiments to increase the selectivity of tumor chemotherapy by means of in vivo activation of transport forms of cancerostatics by exogenous enzymes
Creators Name:	Graffi, A. and Arnold, W. and Sydow, G. and Schwabe, K. and Arndt, D. and Pehl, E.
Abstract:	A significant tumor damaging effect (growth inhibition) on transplanted syngeneic sarcoma in mouse was obtained by means of pH-dependent activation of a transport form of a cancerostatic drug by an enzyme foreign to the organism. This effect was achieved by combined administration of 8-0-(alpha-L-arabinofuranosyl)beta-peltatin-A as a transport form of beta-peltatin-A and the exogenous enzyme alpha-L-arabinofuranosidase from Aspergillus niger and additional increase of the acidity of the tumor by injection of glucose. The combined application of the transport form plus enzyme showed a more favorable effect on selectivity than free peltatin when a quantitative comparison was made between the tumor growth inhibition and the damage to the blood picture.
Keywords:	Peltatin-Arabinoside, Transport Form of Cytostatics, Selective Chemotherapy, Animals, Mice
Source:	Neoplasma
ISSN:	0028-2685
Publisher:	Slovak Academy of Sciences
Volume:	25
Number:	4
Page Range:	377-384
Date:	1978
PubMed:	View item in PubMed

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