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Genetic mapping of a gene causing hypertension in the stroke- prone spontaneously hypertensive rat

Item Type:Article
Title:Genetic mapping of a gene causing hypertension in the stroke- prone spontaneously hypertensive rat
Creators Name:Jacob, H.J. and Lindpaintner, K. and Lincoln, S.E. and Kusumi, K. and Bunker, R.K. and Mao, Y.P. and Ganten, D. and Dzau, V.J. and Lander, E.S.
Abstract:The stroke-prone spontaneously hypertensive rat (SHRSP) is a well-characterized model for primary hypertension in humans. High blood pressure in SHRSP shows polygenic inheritance, but none of the loci responsible have previously been identified. To locate genes controlling this quantitative trait, we mapped a large collection of DNA polymorphisms in a cross between SHRSP and the normotensive WKY strain. Here we report strong genetic evidence that a gene, Bp1, having a major effect on blood pressure maps to rat chromosome 10 with a LOD score of 5.10 and is closely linked to the rat gene encoding angiotensin-converting enzyme (ACE), an enzyme that plays a major role in blood pressure homeostasis and is an important target of anti-hypertensive drugs. We also find significant, albeit weaker, linkage to a locus, Bp2, on chromosome 18. We discuss the implications of genetic dissection of quantitative disease-related phenotypes in mammals.
Keywords:Base Sequence, Blood Pressure, Cerebrovascular Disorders, Chromosome Mapping, Genetic Crosses, Genetic Linkage, Genotype, Hypertension, Lod Score, Molecular Sequence Data, Nucleic Acid Repetitive Sequences, Oligodeoxyribonucleotides, Peptidyl-Dipeptidase A, Animals, Rats
Source:Cell
ISSN:0092-8674
Publisher:Cell Press (U.S.A.)
Volume:67
Number:1
Page Range:213-224
Date:4 October 1991
Official Publication:https://doi.org/10.1016/0092-8674(91)90584-L
PubMed:View item in PubMed

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