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Neurotransmitter receptors on microglia

Official URL:https://doi.org/10.1016/j.tins.2007.07.007
PubMed:View item in PubMed
Creators Name:Pocock, J.M. and Kettenmann, H.
Journal Title:Trends in Neurosciences
Journal Abbreviation:Trends Neurosci
Volume:30
Number:10
Page Range:527-535
Date:October 2007
Keywords:Biological Models, Microglia, Neurotransmitter Agents, Neurotransmitter Receptors, Animals
Abstract:Microglia are the intrinsic immune cells of the brain and express chemokine and cytokine receptors that interact with the peripheral immune cells. Recent studies have indicated that microglia also respond to the brain's classical signalling substances, the neurotransmitters. Here, we review the evidence for the expression of neurotransmitter receptors on microglia and the consequences of this receptor activation for microglial behaviour. It is evident that neurotransmitters instruct microglia to perform distinct types of responses, such as triggering an inflammatory cascade or acquiring a neuroprotective phenotype. Understanding how microglia respond to different neurotransmitters will thus have important implications for controlling the reactivity of these cells in acute injury, as well as for treating chronic neurodegenerative diseases.
ISSN:0166-2236
Publisher:Elsevier (The Netherlands)
Additional Information:The original publication is available at www.sciencedirect.com
Item Type:Review

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