MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb

Item Type:	Article
Title:	MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb
Creators Name:	Xiao, C. and Calado, D.P. and Galler, G. and Thai, T.H. and Patterson, H.C. and Wang, J. and Rajewsky, N. and Bender, T.P. and Rajewsky, K.
Abstract:	MiR-150 is a microRNA (miRNA) specifically expressed in mature lymphocytes, but not their progenitors. A top predicted target of miR-150 is c-Myb, a transcription factor controlling multiple steps of lymphocyte development. Combining loss- and gain-of-function gene targeting approaches for miR-150 with conditional and partial ablation of c-Myb, we show that miR-150 indeed controls c-Myb expression in vivo in a dose-dependent manner over a narrow range of miRNA and c-Myb concentrations and that this dramatically affects lymphocyte development and response. Our results identify a key transcription factor as a critical target of a stage-specifically expressed miRNA in lymphocytes and suggest that this and perhaps other miRNAs have evolved to control the expression of just a few critical target proteins in particular cellular contexts.
Keywords:	MOLIMMUNO, RNA, Animals, Mice
Source:	Cell
ISSN:	0092-8674
Publisher:	Cell Press
Volume:	131
Number:	1
Page Range:	146-159
Date:	5 October 2007
Additional Information:	Erratum in: Cell 165(4): 1027.
Official Publication:	https://doi.org/10.1016/j.cell.2007.07.021
PubMed:	View item in PubMed

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