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The pathogenesis of classical Hodgkin's lymphoma: a model for B-cell plasticity

Item Type:Review
Title:The pathogenesis of classical Hodgkin's lymphoma: a model for B-cell plasticity
Creators Name:Mathas, S.
Abstract:It has been shown that differentiated lymphoid cells can display a broad developmental potential and might even differentiate into other cell types. Recent data implicate such processes in the pathogenesis of classical Hodgkin's lymphoma (HL). In the malignant, B cell-derived Hodgkin's and Reed-Sternberg (HRS) cells of HL the expression of B cell-specific genes is lost, and B lineage-inappropriate genes are up-regulated. Experimental evidence has been presented in recent years that functional disruption of the B lineage–specific transcription factor program contributes to this process. HRS cells might be reprogrammed into cells resembling undifferentiated progenitor cells, which might offer an explanation for the unique HL phenotype and demonstrate a high degree of plasticity of human lymphoid cells.
Keywords:B-Lymphocytes, Cell Differentiation, Hematopoietic Stem Cells, Hodgkin Disease, Phenotype, Reed-Sternberg Cells, Signal Transduction, Transcription Factors
Source:Hematology Oncology Clinics of North America
ISSN:0889-8588
Publisher:Elsevier (The Netherlands)
Volume:21
Number:5
Page Range:787-804
Date:October 2007
Additional Information:The original publication is available at www.sciencedirect.com
Official Publication:https://doi.org/10.1016/j.hoc.2007.06.016
PubMed:View item in PubMed

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