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Suppression of polyploidy by the BRCA2 protein

Item Type:Article
Title:Suppression of polyploidy by the BRCA2 protein
Creators Name:Sagulenko, E. and Savelyeva, L. and Ehemann, V. and Sagulenko, V. and Hofmann, W. and Arnold, K. and Claas, A. and Scherneck, S. and Schwab, M.
Abstract:Mounting evidence implicates BRCA2 not only in maintenance of genome integrity but also in cell-cycle checkpoints. However, the contribution of BRCA2 in the checkpoints is still far from being understood. Here, we demonstrate that breast cancer cells MX-1 are unable to maintain genome integrity, which results in gross polyploidization. We generated MX-1 clones, stably expressing BRCA2, and found that BRCA2 acts to suppress polyploidy. Compared with MX-1, the ectopically BRCA2-expressing cells had different intracellular levels of Aurora A, Aurora B, p21, E2F-1, and pRb, suggesting a BRCA2-mediated suppression of polyploidy via stabilization of the checkpoint proteins levels.
Keywords:BRCA2, Cell-Cycle Checkpoint, Breast Cancer, Polyploidy
Source:Cancer Letters
Page Range:65-72
Date:8 November 2007
Official Publication:https://doi.org/10.1016/j.canlet.2007.07.003
PubMed:View item in PubMed

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