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Low-dose renin inhibitor and low-dose AT(1)-receptor blocker therapy ameliorate target-organ damage in rats harbouring human renin and angiotensinogen genes

Item Type:Article
Title:Low-dose renin inhibitor and low-dose AT(1)-receptor blocker therapy ameliorate target-organ damage in rats harbouring human renin and angiotensinogen genes
Creators Name:Dechend, R. and Shagdarsuren, E. and Gratze, P. and Fiebeler, A. and Pilz, B. and Meiners, S. and Derer, W. and Feldman, D.L. and Webb, R. and Mueller, D.N.
Abstract:We studied the effects of extremely low-dose human renin inhibition (aliskiren) with low angiotensin II receptor blockade (losartan) in a novel double-transgenic rat model harbouring both human renin and angiotensinogen genes. We found that low-dose aliskiren and low-dose losartan effectively reduced mortality and target-organ damage with minimal, non-significant, effects on blood pressure (BP). Our data suggest that renin-angiotensin system (RAS) inhibition ameliorates target-organ damage in an Ang II-driven model of hypertension. Direct renin inhibition is equally efficacious in this regard. Our study does not fully answer the question of BP-lowering versus RAS inhibition. This question is important and was at least partially addressed with our low-dose model.
Keywords:Angiotensin II, Renin inhibitor, Inflammation, Albuminuria, Cardiac damage, Animals, Rats
Source:Journal of the Renin Angiotensin Aldosterone System
ISSN:1470-3203
Publisher:JRAAS (U.K.)
Volume:8
Number:2
Page Range:81-84
Date:June 2007
Official Publication:https://doi.org/10.3317/jraas.2007.008
PubMed:View item in PubMed

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