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The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells

Item Type:Article
Title:The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells
Creators Name:Chen, Y. and Xu, H. and Liu, J. and Zhang, C. and Leutz, A. and Mo, X.
Abstract:Apoptosis of vascular smooth muscle cell (VSMC) is one of the major pathologic features in atherosclerosis. The platelet-derived growth factor (PDGF) pathway has been shown to provide survival signals in VSMCs and PDGF receptors are also highly expressed in VSMCs contained in the plaques of atherosclerosis. However, the downstream targets of PDGF signaling are unclear. In the current study, we show that PDGF signals stimulate the protein expression of c-Myb in human arterial VSMCs. Inhibition of c-Myb function in VSMCs enhanced apoptosis in PDGF treated VSMCs. Our data suggest that c-Myb functions as a downstream target of the PDGF survival pathway and suggest that c-Myb plays an essential role in adult VSMC survival.
Keywords:c-Myb, Vascular Smooth Muscle Cell, Apoptosis, PDGF
Source:Biochemical and Biophysical Research Communications
ISSN:0006-291X
Publisher:Academic Press (U.S.A.)
Volume:360
Number:2
Page Range:433-436
Date:24 August 2007
Additional Information:The original publication is available at www.sciencedirect.com
Official Publication:https://doi.org/10.1016/j.bbrc.2007.06.078
PubMed:View item in PubMed

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