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Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT

Item Type:Article
Title:Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT
Creators Name:Yde, C.W. and Frogne, T. and Lykkesfeldt, A.E. and Fichtner, I. and Issinger, O.G. and Stenvang, J.
Abstract:Protein kinase CK2 is involved in cell proliferation and survival, and found overexpressed in virtually all types of human cancer, including breast cancer. We demonstrate that inhibition of CK2 with 2-dimethylamino-4,5,6,7-tetrabromo-benzimidazole (DMAT), a potent and specific CK2 inhibitor, results in caspase-mediated killing of human breast cancer cells with acquired resistance to antiestrogens, while DMAT fails to kill parental MCF-7 cells. The antiestrogen resistant breast cancer cells express reduced levels of Bcl-2 compared to MCF-7 cells. Reduced Bcl-2 protein level is also found in a tamoxifen resistant human breast tumor grown as a xenograft. We show that re-expression of Bcl-2 partially rescues antiestrogen resistant MCF-7 sublines from DMAT-induced cell death. In summary, our data suggest a novel role of CK2 in antiestrogen resistance.
Keywords:CK2, DMAT, Breast Cancer, Antiestrogen Resistance, Apoptosis, Bcl-2
Source:Cancer Letters
ISSN:0304-3835
Publisher:Elsevier (The Netherlands)
Volume:256
Number:2
Page Range:229-237
Date:28 October 2007
Official Publication:https://doi.org/10.1016/j.canlet.2007.06.010
PubMed:View item in PubMed

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