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Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling

Item Type:Article
Title:Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling
Creators Name:Yin, H. and Chao, J. and Bader, M. and Chao, L.
Abstract:We investigated the role of kinin receptors in cardiac remodeling after ischemia/reperfusion (I/R). Bradykinin injection improved cardiac contractility, diastolic function, reduced infarct size and prevented left ventricular thinning after I/R, whereas des-Arg(9)-BK injection had no protective effects. Bradykinin, but not des-Arg(9)-BK, reduced cardiomyocyte apoptosis and increased Akt and GSK-3beta phosphorylation. Furthermore, myocardial infarct size was similar between wild type and B2 knockout mice after I/R, but significantly reduced in kinin B1 receptor knockout mice. These results indicate that the kinin B2 receptor, but not the B1 receptor, protects against I/R-induced cardiac dysfunction by inhibiting apoptosis and limiting ventricular remodeling.
Keywords:B1 receptor, B2 receptor, Bradykinin, Ischemia/reperfusion, Remodeling, Animals, Mice, Rats
Source:Peptides
ISSN:0196-9781
Publisher:Elsevier (The Netherlands)
Volume:28
Number:7
Page Range:1383-1389
Date:July 2007
Official Publication:https://doi.org/10.1016/j.peptides.2007.05.010
PubMed:View item in PubMed

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