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Do autochthonous tumors interfere with effector T cell responses?

Item Type:Review
Title:Do autochthonous tumors interfere with effector T cell responses?
Creators Name:Blankenstein, T.
Abstract:The assumption that autochthonous tumors interfere with the effector T cell (T(E)) response implies that they first induce functional T cells. However, if T(E) are generated, they usually remain functional, persist life-long as memory cells and prevent tumors. This holds true for some virus-induced tumors and is associated with evolutionary pressure. In contrast, models that allow monitoring of tumor antigen-specific T cells suggest that spontaneous autochthonous tumors either sneak through or induce T(E) too late when the tumor has developed resistance to T(E) or induce tolerance. This can be explained by the absence of evolutionary pressure.
Keywords:Effector T Cells, Autochthonous Tumors, Cancer Immunosurveillance, Tolerance, Immunity, Animals
Source:Seminars in Cancer Biology
ISSN:1044-579X
Publisher:Elsevier / Academic Press (U.K.)
Volume:17
Number:4
Page Range:267-274
Date:August 2007
Additional Information:The original publication is available at www.sciencedirect.com
Official Publication:https://doi.org/10.1016/j.semcancer.2007.06.007
PubMed:View item in PubMed

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