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Systematic functional assessment of human protein-protein interaction maps

Item Type:Article
Title:Systematic functional assessment of human protein-protein interaction maps
Creators Name:Chaurasia, G. and Herzel, H. and Wanker, E.E. and Futschik, M.E.
Abstract:Protein-protein interaction maps can contribute substantially to the discovery of protein cooperation patterns in the cell. Recently, several large-scale human protein-protein interaction maps have been generated using experimental or computational approaches. Evaluation of these maps is likely to provide a better understanding of human biology. However, careful analysis is needed, as the comparison of interaction maps of lower eukaryotes showed a surprising divergence between different maps. Here, we present a first systematic functional assessment of eight currently available large-scale human protein-protein interaction maps. The analysis shows that these maps include a large number of common proteins, but only a small number of common interactions. We detected several types of biases that need to be considered in the future utilization of these maps.
Keywords:Protein-protein interaction, Human interactome, Networks, Systems biology
Source:Genome Inform
Publisher:Universal Academy Press
Page Range:36-45
PubMed:View item in PubMed

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