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Water drinking induces thermogenesis through osmosensitive mechanisms

Item Type:Article
Title:Water drinking induces thermogenesis through osmosensitive mechanisms
Creators Name:Boschmann, M. and Steiniger, J. and Franke, G. and Birkenfeld, A.L. and Luft, F.C. and Jordan, J.
Abstract:Context. Recently, we showed that drinking 500 ml water induces thermogenesis in normal-weight men and women. Objective. We now repeated these studies in a randomized, controlled, crossover trial in overweight or obese, otherwise healthy subjects (8 men and 8 women) comparing also the effects of 500 ml iso-osmotic saline or 50 ml water. Results. Only 500 ml water increased energy expenditure by 24% over the course of 60 minutes after ingestion, while iso-osmotic saline and 50 ml water had no effect. Heart rate and blood pressure did not change in these young, healthy subjects. Conclusions. Our data exclude volume-related effects or gastric distension as the mediator of the thermogenic response to water drinking. Instead, we hypothesize the existence of a portal osmoreceptor, most likely an ion channel.
Keywords:Automonic, Calorimetry, Circulation, Metabolism, Sympathetic
Source:Journal of Clinical Endocrinology and Metabolism
ISSN:0021-972X
Publisher:Endocrine Society (U.S.A.)
Volume:92
Number:8
Page Range:3334-3337
Date:August 2007
Official Publication:https://doi.org/10.1210/jc.2006-1438
PubMed:View item in PubMed

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