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A transgenic rat expressing human APP with the Swedish Alzheimer's disease mutation

Item Type:Article
Title:A transgenic rat expressing human APP with the Swedish Alzheimer's disease mutation
Creators Name:Folkesson, R. and Malkiewicz, K. and Kloskowska, E. and Nilsson, T. and Popova, E. and Bogdanovic, N. and Ganten, U. and Ganten, D. and Bader, M. and Winblad, B. and Benedikz, E.
Abstract:In recent years, transgenic mice have become valuable tools for studying mechanisms of Alzheimer's disease (AD). With the aim of developing an animal model better for memory and neurobehavioural testing, we have generated a transgenic rat model of AD. These animals express human amyloid precursor protein (APP) containing the Swedish AD mutation. The highest level of expression in the brain is found in the cortex, hippocampus, and cerebellum. Starting after the age of 15 months, the rats show increased tau phosphorylation and extracellular Abeta staining. The Abeta is found predominantly in cerebrovascular blood vessels with very rare diffuse plaques. We believe that crossing these animals with mutant PS1 transgenic rats will result in accelerated plaque formation similar to that seen in transgenic mice.
Keywords:Alzheimer's disease, Amyloid precursor protein, Transgenic, Amyloid, Tau, Animals, Rats
Source:Biochemical and Biophysical Research Communications
ISSN:0006-291X
Publisher:Academic Press (U.S.A.)
Volume:358
Number:3
Page Range:777-782
Date:6 July 2007
Additional Information:The original publication is available at www.sciencedirect.com
Official Publication:https://doi.org/10.1016/j.bbrc.2007.04.195
PubMed:View item in PubMed

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