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Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain

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Item Type:Article
Title:Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain
Creators Name:Sieber, M.A. and Storm, R. and Martinez-de-la-Torre, M. and Mueller, T. and Wende, H. and Reuter, K. and Vasyutina, E. and Birchmeier, C.
Abstract:Distinct types of relay neurons in the hindbrain process somatosensory or viscerosensory information. How neurons choose between these two fates is unclear. We show here that the homeobox gene Lbx1 is essential for imposing a somatosensory fate on relay neurons in the hindbrain. In Lbx1 mutant mice, viscerosensory relay neurons are specified at the expense of somatosensory relay neurons. Thus Lbx1 expression distinguishes between the somatosensory or viscerosensory fate of relay neurons.
Keywords:Neuronal specification, Homeobox gene, Nucleus of the solitary tract, Spinal trigeminal nucleus, Genetic lineage tracing, Development, Animals, Mice
Source:Journal of Neuroscience
ISSN:0270-6474
Publisher:Society for Neuroscience (U.S.A.)
Volume:27
Number:18
Page Range:4902-4909
Date:2 May 2007
Additional Information:Copyright (c) 2007 by The Society for Neuroscience
Official Publication:https://doi.org/10.1523/JNEUROSCI.0717-07.2007
PubMed:View item in PubMed

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