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Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis

Item Type:Article
Title:Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis
Creators Name:Lietz, A. and Janz, M. and Sigvardsson, M. and Jundt, F. and Doerken, B. and Mathas, S.
Abstract:Similar to classical Hodgkin lymphoma (HL) tumour cells, primary effusion lymphoma (PEL) originates from mature B cells but displays a non-B cell phenotype, the mechanisms and consequences of which are not yet understood. This study showed that PEL lacked DNA binding activity of the B cell-determining transcription factors E2A, EBF and Pax5. PEL overexpressed the E2A antagonists ABF-1 and Id2, which have been described to block the B-cell differentiation program in classical HL. However, in contrast to HL cells, B lineage-inappropriate genes were not similarly upregulated in PEL, and reconstitution of B cell-specific E2A homodimer activity in PEL induced apoptosis. These data demonstrate that lineage infidelity in PEL is not as pronounced as in HL, and that the loss of the B cell-specific transcription factor E2A in PEL is implicated in apoptosis protection.
Keywords:Lymphoma, Primary Effusion Lymphoma, E2A, Hodgkin Lymphoma
Source:British Journal of Haematology
ISSN:0007-1048
Publisher:Blackwell Publishing (U.K.)
Volume:137
Number:4
Page Range:342-348
Date:May 2007
Official Publication:https://doi.org/10.1111/j.1365-2141.2007.06583.x
PubMed:View item in PubMed

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