Helmholtz Gemeinschaft


Regulation of the germinal center response by microRNA-155

Item Type:Article
Title:Regulation of the germinal center response by microRNA-155
Creators Name:Thai, T.H. and Calado, D.P. and Casola, S. and Ansel, K.M. and Xiao, C. and Xue, Y. and Murphy, A. and Frendewey, D. and Valenzuela, D. and Kutok, J.L. and Schmidt-Supprian, M. and Rajewsky, N. and Yancopoulos, G. and Rao, A. and Rajewsky, K.
Abstract:MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.
Keywords:B-Lymphocytes, Cell Differentiation, Cultured Cells, Cytokines, Germinal Center, Immunoglobulin G, Lymphocyte Activation, Lymphotoxin-alpha, Lymphotoxin-beta, MicroRNAs, Nitrophenols, Peyer's Patches, Phenylacetates, Immunoglobulin Somatic Hypermutation, Spleen, T-Lymphocytes, Th1 Cells, Th2 Cells, Tumor Necrosis Factor-alpha, Animals, Mice
Publisher:American Association for the Advancement of Science
Page Range:604-608
Date:27 April 2007
Official Publication:https://doi.org/10.1126/science.1141229
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library