Item Type: | Article |
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Title: | Regulation of the germinal center response by microRNA-155 |
Creators Name: | Thai, T.H. and Calado, D.P. and Casola, S. and Ansel, K.M. and Xiao, C. and Xue, Y. and Murphy, A. and Frendewey, D. and Valenzuela, D. and Kutok, J.L. and Schmidt-Supprian, M. and Rajewsky, N. and Yancopoulos, G. and Rao, A. and Rajewsky, K. |
Abstract: | MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo. |
Keywords: | B-Lymphocytes, Cell Differentiation, Cultured Cells, Cytokines, Germinal Center, Immunoglobulin G, Lymphocyte Activation, Lymphotoxin-alpha, Lymphotoxin-beta, MicroRNAs, Nitrophenols, Peyer's Patches, Phenylacetates, Immunoglobulin Somatic Hypermutation, Spleen, T-Lymphocytes, Th1 Cells, Th2 Cells, Tumor Necrosis Factor-alpha, Animals, Mice |
Source: | Science |
ISSN: | 0036-8075 |
Publisher: | American Association for the Advancement of Science |
Volume: | 316 |
Number: | 5824 |
Page Range: | 604-608 |
Date: | 27 April 2007 |
Official Publication: | https://doi.org/10.1126/science.1141229 |
PubMed: | View item in PubMed |
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