Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy

Item Type:	Review
Title:	Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy
Creators Name:	Pagel-Langenickel, I. and Buttgereit, J. and Bader, M. and Langenickel, T.H.
Abstract:	Natriuretic peptides (NP) represent a family of structurally homologous but genetically distinct peptide hormones involved in regulation of fluid and electrolyte balance, blood pressure, fat metabolism, cell proliferation, and long bone growth. Recent work suggests a role for natriuretic peptide receptor B (NPR-B) signaling in regulation of cardiac growth by either a direct effect on cardiomyocytes or by modulation of other signaling pathways including the autonomic nervous system. The research links NPR-B for the first time to a cardiac phenotype in vivo and underlines the importance of the NP in the cardiovascular system. This manuscript will focus on the role of NPR-B and its ligand C-type natriuretic peptide in cardiovascular physiology and disease and will evaluate these new findings in the context of the known function of this receptor, with a perspective on how future research might further elucidate NPR-B function.
Keywords:	Cardiac Hypertrophy, Natriuretic Peptide Receptor B, C-Type Natriuretic Peptide, Cardiovascular, Animals
Source:	Journal of Molecular Medicine
ISSN:	0946-2716
Publisher:	Springer
Volume:	85
Number:	8
Page Range:	797-810
Date:	August 2007
Official Publication:	https://doi.org/10.1007/s00109-007-0183-4
PubMed:	View item in PubMed

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