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| Item Type: | Article |
|---|---|
| Title: | c-Met is essential for wound healing in the skin |
| Creators Name: | Chmielowiec, J. and Borowiak, M. and Morkel, M. and Stradal, T. and Munz, B. and Werner, S. and Wehland, J. and Birchmeier, C. and Birchmeier, W. |
| Abstract: | Wound healing of the skin is a crucial regenerative process in adult mammals. We examined wound healing in conditional mutant mice, in which the c-Met gene that encodes the receptor of hepatocyte growth factor/scatter factor was mutated in the epidermis by cre recombinase. c-Met-deficient keratinocytes were unable to contribute to the reepithelialization of skin wounds. In conditional c-Met mutant mice, wound closure was slightly attenuated, but occurred exclusively by a few (5%) keratinocytes that had escaped recombination. This demonstrates that the wound process selected and amplified residual cells that express a functional c-Met receptor. We also cultured primary keratinocytes from the skin of conditional c-Met mutant mice and examined them in scratch wound assays. Again, closure of scratch wounds occurred by the few remaining c-Met-positive cells. Our data show that c-Met signaling not only controls cell growth and migration during embryogenesis but is also essential for the generation of the hyperproliferative epithelium in skin wounds, and thus for a fundamental regenerative process in the adult. |
| Keywords: | Autocrine Communication, Cultured Cells, Hepatocyte Growth Factor, Integrases, Keratinocytes, Mutation, Proto-Oncogene Proteins c-met, Signal Transduction, Skin Physiology, Wound Healing, Knockout, Animals, Mice |
| Source: | Journal of Cell Biology |
| ISSN: | 0021-9525 |
| Publisher: | Rockefeller University Press |
| Volume: | 177 |
| Number: | 1 |
| Page Range: | 151-162 |
| Date: | 9 April 2007 |
| Official Publication: | https://doi.org/10.1083/jcb.200701086 |
| PubMed: | View item in PubMed |
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