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RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells

Item Type:Article
Title:RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells
Creators Name:Vasyutina, E. and Lenhard, D.C. and Wende, H. and Erdmann, B. and Epstein, J.A. and Birchmeier, C.
Abstract:In the developing muscle, a pool of myogenic progenitor cells is formed and maintained. These resident progenitors provide a source of cells for muscle growth in development and generate satellite cells in the perinatal period. By the use of conditional mutagenesis in mice, we demonstrate here that the major mediator of Notch signaling, the transcription factor RBP-J, is essential to maintain this pool of progenitor cells in an undifferentiated state. In the absence of RBP-J, these cells undergo uncontrolled myogenic differentiation, leading to a depletion of the progenitor pool. This results in a lack of muscle growth in development and severe muscle hypotrophy. In addition, satellite cells are not formed late in fetal development in conditional RBP-J mutant mice. We conclude that RBP-J is required in the developing muscle to set aside proliferating progenitors and satellite cells.
Keywords:Muscle Differentiation, Myogenic Progenitors, Notch Signaling, Animals, Mice
Source:Proceedings of the National Academy of Sciences of the United States of America
Publisher:National Academy of Sciences (U.S.A.)
Page Range:4443-4448
Date:13 March 2007
Official Publication:https://doi.org/10.1073/pnas.0610647104
PubMed:View item in PubMed

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