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Beta-catenin regulates P-cadherin expression in mammary basal epithelial cells

Item Type:Article
Title:Beta-catenin regulates P-cadherin expression in mammary basal epithelial cells
Creators Name:Faraldo, M.M. and Teuliere, J. and Deugnier, M.A. and Birchmeier, W. and Huelsken, J. and Thiery, J.P. and Cano, A. and Glukhova, M.A.
Abstract:P-cadherin expression is restricted to the basal layer of stratified epithelia including that of the mammary gland. Although evidence for an important role of P-cadherin in mammary morphogenesis and tumorigenesis is increasing, the mechanisms that regulate its expression are poorly understood. We show that in basal mammary epithelial cells, beta-catenin is associated with the P-cadherin promoter and activates its expression independently of LEF/TCF in a cell-type specific manner. Down-regulation of endogenous beta-catenin levels by RNA interference technique inhibited P-cadherin promoter activity. In vivo, in skin and mammary gland of mutant mice, activation of beta-catenin signalling correlates with up-regulation of P-cadherin expression. These data suggest that beta-catenin-dependent modulation of P-cadherin expression can contribute to the establishment of the basal phenotype.
Keywords:Basal epithelial cell, Beta-catenin, Mammary gland, P-cadherin promoter, Animals, Mice
Source:FEBS Letters
Page Range:831-836
Date:6 March 2007
Official Publication:https://doi.org/10.1016/j.febslet.2007.01.053
PubMed:View item in PubMed

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