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Transcription factors in myeloid development: balancing differentiation with transformation

Official URL:https://doi.org/10.1038/nri2024
PubMed:View item in PubMed
Creators Name:Rosenbauer, F. and Tenen, D.G.
Journal Title:Nature Reviews Immunology
Journal Abbreviation:Nat Rev Immunol
Volume:7
Number:2
Page Range:105-117
Date:February 2007
Keywords:Cell Differentiation, Cell Lineage, Hematopoietic Stem Cells, Myeloid Leukemia, Neoplastic Cell Transformation, Transcription Factors, Animals, Mice
Abstract:In recent years, great progress has been made in elucidating the progenitor-cell hierarchy of the myeloid lineage. Transcription factors have been shown to be key determinants in the orchestration of myeloid identity and differentiation fates. Most transcription factors show cell-lineage-restricted and stage-restricted expression patterns, indicating the requirement for tight regulation of their activities. Moreover, if dysregulated or mutated, these transcription factors cause the differentiation block observed in many myeloid leukaemias. Consequently, therapies designed to restore defective transcription factor functions are an attractive option in the treatment of myeloid and other human cancers.
ISSN:1474-1733
Publisher:Nature Publishing Group (U.K.)
Item Type:Review

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